The main A487 road was closed both ways in Aberaeron on Saturday while emergency services dealt with a fire on the town’s Bridge Street.
Dyfed-Powys Police confirmed at 12.30pm that the road was impassable, due to emergency vehicles being at the scene.
Firefighters from both Aberaeron and New Quay dealt with the fire at a building premises in the town.
A police spokesman said: “We kindly ask you to find alternative routes if possible and to avoid the area."
An update on social media at 4.30pm confirmed that the road had reopened.
"Bridge Street in Aberaeron is now passable for traffic," said a police spokesman.
"Thank you for your patience."
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